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Enzyme critical to kidney health could support 700 million people worldwide

Credit: Robina Weermeijer on unplanned.

University of South Australia Researchers have identified an enzyme that can help to curb chronic kidney disease that affects around 700 million people worldwide.

This enzyme, NEDD4-2, is crucial for kidney health, says Unisa Center for Cancer Biology Scientists Dr. med. Jantina-manning in a new paper published this month in cell death & disease .

The early career researcher and her colleagues, including 2020 SA scientists of the Year Professor Sharad Kumar, have studied in an animal in an animal, which examines the correlation between a high salt diet, a low NEDD4-2- and advanced kidney disease.

. If a high salt diet can aggravate some forms of kidney disease, researchers did not know that NEDD4-2 plays a role in promoting this salt-induced kidney damage.

"We now know that both a high sodium diet and a low NEDD4-2 mirror promote the renal-disease progression, even if it is in the absence of high blood pressure, which is usually hand in hand with increased sodium," Says dr teaming.

nedd4-2 regulates the path required for sodium absorption path required in kidneys to ensure that the correct salt grades are maintained. When the NEDD4-2 protein is reduced or locked, increased salt absorption can lead to kidney damage.

Even people on a low salt diet can get kidney damage if they have low NEDD4-2 due to genetic variations or mutations.

Prof Kumar says the long-term goal is to develop a drug that can increase NEDD4-2 levels in people with chronic kidney disease (CKD).

"We are now testing different strategies to ensure that this protein will maintain all the time for all kidney health at a normal level," says Prof Kumar.

"In diabetic nephropathy - a common cause of kidney disease - NEDD4-2 are greatly reduced. This is the case, even if salt is not a factor."

The study also showed a surprising find: that high salt diet-induced kidney disease is not always due to high blood pressure.

In many cases, renal disease is tightened by hypertension, so we wanted to examine this link in our study. In fact, we found the complete opposite - that a high salt diet led to excessive water loss and low blood pressure. This is important because it means that the kidney disease can happen even in people who have no high blood pressure, "dr teaming says.

a 2020 Lancet paper estimated that about 700 million people - or 10 percent of the world's population - suffer from chronic kidney disease, which increases a rise of 29 percent in the last 30 years.

The huge tip in CKD is mainly due to a global obesity epidemic in recent decades, resulting in diabetes, one of the leading causes of chronic kidney disease along with high blood pressure.

World Health Organization Statistics show an increase of 300 percent in the increase in diabetes between 1980 and 2014, which is one of the world's top 10 causes of death and the gravity of the problem shows that the scientist causes kidney disease to be found.

"Obesity and lifestyle are two major factors that drive chronic kidney diseases, but also gives other things in the game," Dr. Manning. "Acute renal injuries, drugs taken on other conditions, high blood pressure and a genetic predisposition can also lead."

Cell death & disease. 2021; 12 (4): 398. DOI: 10.1038 / S .

This article has been released again from the following materials. Note: The material may have been processed for length and content.For more information, please contact the quoted source.

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